The East London Guardian Series is hoping fans will enjoy interacting pre-match, during the game and after the final whistle has blown on our website.
Twitter users can contribute just by adding the #LOFC hashtag and for those of you not on the social networking site, you can still read the comments here and add your own views in the Guardian's comment section below.
If you have any questions for our reporter about the match or other O's-related matters then you can contact him via Twitter by tweeting @GuardianOrient.
Key points:
Ryan Lowe's first half goal enough to seal 1-0 victory for MK Dons.
Kevin Lisbie comes on for Orient but can't prevent fourth consecutive defeat.
The O's slip to 20th in League One, just two points above the relegation zone.
MK Dons: Martin, Ostemobor, Lewington, Williams, Gleeson, Potter, Bowditch, Lowe, Kay, Chadwick, Balanta
Subs: McLoughlin, Kouo-Doumbe, Macdonald, Smith, Chicksen, Ali, Sekajja
Leyton Orient: Allsop, Sawyer, Chorley, Griffith, Clarke, Odubajo, Cook, Rowlands, James, Wagstaff, Mooney
Subs: Jones, McSweeney, Baudry, Cox, Lisbie, Smith, Brunt
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