The Guardian Series is hoping fans will enjoy interacting pre-match, during the game and after the final whistle has blown on our website.
Twitter users can contribute just by adding the #lofc hashtag and for those of you not on the social networking site, you can still read the comments here and add your own views in the comment section below.
If you have any questions for our reporter about the match or other Orient related matters then you can contact him via Twitter by tweeting @GuardianOrient.
Key points
• David Mooney's first-half effort ruled out for offside. Orient open the scoring with a first-half header from Mathieu Baudry.
• The O's make it 2-0 in the second half as striker Kevin Lisbie finds the net.
• Leyton Orient make one change with captain Nathan Clarke missing out with an ankle injury as Baudry starts in defence.
Leyton Orient line-up
Allsop; Sawyer, Chorley, Baudry, Odubajo; Cox, Cook (Griffith, 72), Rowlands, James; Mooney (Brunt, 86), Lisbie
Subs not used: Jones, McSweeney, Cuthbert, Smith, Smith
Preston line-up
Simonsen; Huntington, Robertson, Kane, Buchanan; Wright (Cummins, 58), Wroe, Holmes, Welsh; King (Sodje, 68), Beavon (Elding, 80)
Subs not used: Stuckmann, Cansdell-Sherriff, Amoo, Byrom
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here