Orient arrived looking for a third straight win at the Galpharm Stadium, but this was a day of such slim pickings up in Yorkshire and comprehensive defeat.
The canny host's won the toss and had Orient play into the glare of the sun.
And there was no doubt which was the home side throughout this game.
Huddersfield scored four goals, as Orient showed real problems dealing with the crosses which flew into Glenn Morris' area from all angles for 93 minutes.
Orient had to work hard for everything. Luke Summerfield and Andros Townsend looked the most dangerous for the visitor's. Scott McGleish had little to fed upon except high balls from the back.
The Terriers tested Orient's defence all through the first 45 minutes. The O's back-line held firm under a bombardment of crosses from either side, but succumbed right on half time.
Then, Roberts was in the right place 12 yards out on the left of the area to gather the loose ball after strike a shot into the far corner past Morris.
Morris was sharp on three minutes to save Anthony Pilkington slow shot after Two minutes later, Gary Robert's speculative long range volley from near the left touch-line forced Morris to make another save.
It brought Orient boss Geraint Williams to the edge of his technical area.
The opening 10 minutes belonged to the Terriers. O's defenders tried to reach Ryan Jarvis and Scott McGleish with long balls.
Huddersfield striker Lee Novak and Jordan Rhodes, who started the game on 11 goals, were playing on the shoulders of the O's back line.
Jason Demetriou provided the first joy for travelling Orient fans with a piece of trickery near the corner flag where he evaded two challenges.
Andros Townsend, starting, was the first O's player to run at and take on Huddersfield on 17 minutes.
Ben Chorley should have scored with his head from Luke Summerfield's corner which Townsend's run had created.
But soon afterwards, Gary Roberts cut through Cave-Brown and Chorley into the six yard box which Charlie Daniels needed to head clear from Novak, who was lurking.
During the first half hour, Orient gave the ball away a little too readily in their own final third.
But the O's were also starting to impose themselves at the other end. Summerfield and Smith each had shots from just outside the area.
Morris made another great save low to his left after Novak had managed to slice a pass to Roberts into the six yard box after tumbling by the touchline. Orient's stand-in keeper dealt well with the unexpected effort.
Up front, it was loan pair Summerfield and Townsend creating most of the problems for Huddersfield with medium-range shots as Orient struggled to carve out openings from themselves.
The Terriers utilised the flanks to send in crosses that always looked likely to cause Orientui; problems After holding out for 45 minutes, it was a corner which led to Town's goal. Roberts And it was service resumed in the second half.
Skipper Nathan Clarke doubled Huddersfield's advantage on 57 minutes when he rose at the far post to head home ... corner.
Orient first shot on target in the game came via Jimmy Smith soon afterwards. It was easily collected by keeper Alex Smithies.
Williams juggled with the formation in search of a spark on the hour mark.
Demetriou went to right back as Melligan came on and went wide midfield. James Scowcroft replaced McGleish, who had been anonymous.
Minutes later, Adrian Patulea replaced Ryan Jarvis, whose linking play and eye for a pass had made him one of Orient's most effective players.
The changes made no difference to the course of the match as Huddersfield were totally dominant.
As if to underline it, Michael Collins headed the host's third goal on 74 minutes at the far post.
There was little Morris could do about that goal, but he continued to impress, rushing out and saving well substitute Lionel Ainsworth's effort on 86 minutes.
The Terriers' Jordan Rhodes made it four at the end of normal time with yet another header.
4-0 Huddersfield. The best that can be said for Orient is that at least only 208 fans braved the journey and the weather to witness it.
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