Orient boss Geraint Williams gives 17 year-old youth team defender Cestor Mike his first taste of first team action with a place on the subs bench.
Ryan Jarvis misses his second game due to illness. Scott McGleish and Adrian Patulea start up-front.
McGleish plays despite a head-wound which forced him off the pitch at Brighton on Boxing Day.
Luke Ashworth deputises at the back in place of Stephen Purches. Tamika Mkandawire wears the skipper's armband.
Jones, Chorley, Mkandawire, Ashwoth, Melligan, Chambers, McGleish, Cave-Brown, Smith, Patulea, Townsend.
Subs: Morris (GK) Demetriou, Pires, Baker, Mike, Beautyman.
Southend: Joyce, Francis, Malone, Morrison, Barett (c), Grant, mcCormak, Barnard,, Scannell, Moussa, Laurent.
Subs: Christophe, Walker, Sankofa, Freedman, Herd, O'Keefe, Bentley (GK)
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