The Guardian Series is hoping fans will enjoy interacting pre-match, during the game and after the final whistle has blown on our website.
Twitter users can contribute just by adding the #lofc hashtag and for those of you not on the social networking site, you can still read the comments here and add your own views in the comment section below.
If you have any questions for our reporter about the match or other Orient related matters then you can contact him via Twitter by tweeting @GuardianOrient.
Key points
• Colchester United take a first-half lead when Anthony Wordsworth curls the ball into the net.
• The visitors added a second goal after 51 minutes through Ian Henderson.
• Leyton Orient make one change from the defeat at Oldham with Dean Cox starting in place of Anthony Griffith.
Leyton Orient line-up
Allsop; Chorley, Clarke, McSweeney, Sawyer; Cox (Cook, 62), Smith, Odubajo, Rowlands, Wagstaff; Brunt (Mooney, 62)
Subs not used: Jones, Baudry, Griffith, Symes, James
Colchester United line-up
Cousins; Rose, Okunghae, Eastman, Wilson; Eastmond (O'Toole, 80), Bean (Duguid, 84), Wordsworth, Ibehre, Henderson; Massey (Sears, 75)
Subs not used: Nkumu, White, Wright, Pentney
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here